The mechanistic significance of centrosome aberrations for the induction of chromosomal instability has been a matter of intensive debate as well. On the one hand, it has been proposed that abnormal ...

Biologists at the National University of Singapore (NUS) have uncovered how the protein NuSAP safeguards tiny structures inside cells called centrioles, revealing a mechanism linked to developmental ...

Centrosome duplication and numeric integrity are controlled by cell-cycle regulatory proteins, as well as by other factors mediating DNA-damage response and/or repair mechanisms and nucleocytoplasmic ...

Biologists at the National University of Singapore (NUS) have uncovered how the protein NuSAP safeguards tiny structures inside cells called ...

In humans and other mammals, cardiac muscle cells stop replicating soon after birth, unlike the cardiac muscle cells in, say, zebrafish and amphibians. What do zebrafish and amphibian cardiomyocytes ...

A tiny, freshwater flatworm found in ponds and rivers around the world that has long intrigued scientists for its remarkable ability to regenerate has now added a new wrinkle to biology. Reporting in ...

Intra-patient genomic heterogeneity of single circulating tumor cells (CTCs) associated to phenotypic CTC heterogeneity in metastatic castrate resistant prostate cancer (mCRPC). SOD2 rs4880 CT/CC ...

Researchers from the DZNE have solved an important puzzle in neurobiology: the wiring and the movement of nerve cells are interwoven, but separately controlled. The study focuses on neuronal growth ...

New research links gene mutations found in some patients with Meier-Gorlin syndrome (MGS) with specific cellular dysfunctions that are thought to give rise to a particularly extreme version of ...

Clinical applications of genetic sequencing in lymphoma: A retrospective review. Concordance of PD-L1 expression detection in non-small cell lung cancer (NSCLC) tissue biopsies between OncoTect iO ...

A recent Cell Reports paper by the Oxenius group (IMB) demonstrates a function of targeted centrosome inheritance during CD8+ T cell division for the generation of memory precursor cells.

Unseen and ongoing, thousands of times every second: to keep a complex organism like humans alive, an immense number of new cells must be continuously produced. Up close, each of these cell divisions ...